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During perimenopause, the ovaries gradually produce less estrogen, leading to various physical and emotional changes

where variant allele frequency (VAF) is close to 11% (0.107388)

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Deficiencies in glutamate uptake and the glutamate-glutamine cycle can lead to problems in neuronal signaling and promotes excitotoxicity (reviewed by Danbolt, 2001

Sever et al., 2009

It also promotes nerve regeneration after physical transection, meaning it does not just protect neurons from dying but actively supports the regrowth of damaged nerve fibers