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Weight regain is common after discontinuation if lifestyle modifications are not maintained

While pharmaceutical GLP-1 agonists work through direct receptor stimulation, dihydroberberine appears to work through multiple complementary pathways, supporting not only GLP-1 production but also enhancing insulin sensitivity and reducing oxidative stress

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Clinical trials demonstrate that Saxenda leads to average weight loss of 5-7.5% of initial body weight at one year, with success rates of 50-81% of patients achieving clinically meaningful weight loss of 5% body weight