In June 2021, Biogen received FDA approval for Aduhelm (aducanumab), the first new Alzheimers disease treatment approved in nearly two decades, and the first to supposedly target the disease process itself rather than the symptoms
reported that the relative abundances of Oscillibacter , Bilophila , UBA1819, Ruminococcaceae UCG-004, Anaerotruncus , and Ruminococcaceae NK4A214 increased in DKD patients compared with non-DKD controls [125]
10.1038/s41556-020-0461-8 44 LeeJ.ShinD.RohJ
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The risk association remained strong in trials that ran 104 weeks or longer, showing an odds ratio of 1.76 (95% CI: 1.00, 3.12) [1]
Several factors may explain this paradoxical response, though there is no official established link between tirzepatide and increased hunger in the prescribing information
