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Additionally, animal studies have found that GLP-1 may impact areas of the brain involved in appetite regulation and reward perception

In ACHIEVE-1, 559 adults with early type 2 diabetes received placebo or orforglipron at multiple doses, with the maximum studied dose being 36 mg daily

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Stable body weight (5 kg) within 90 days of screening and at least one self-reported unsuccessful dietary effort to lose weight were also required

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The main therapeutic goal is to enhance clinical outcomes while minimizing adverse effects, surpassing the efficacy of similar products from rival pharmaceutical firms