doi:10.1001/jamaneurol.2025.2020 MSc
By stimulating these two hormone pathways simultaneously, tirzepatide regulates appetite, slows gastric emptying, improves insulin sensitivity, and promotes fat mobilization, producing greater, more sustained weight loss than GLP-1-only therapies like semaglutide
The article recommends thyroid peroxidase antibodies as part of the baseline panel when autoimmune thyroid disease is suspected, alongside TSH and free T4
This isnt lemmes first allegation, however
Notably, a Business Group on Health survey fielded earlier this year found that 87% of employers expect the availability of oral medications to increase demand for GLP-1s, while only 9% predict a price drop
Because the article frames this as an absence of data rather than a finding of safety or harm, which is exactly why caution is the default