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To investigate whether inhibition of Gpx induces T-cell hyporesponsiveness, we pretreated 0.4 mM MS (Gpx inhibitor, Sigma-Aldrich) for 48 h, then treated Con A (5 g/ml) for 8 h in Jurkat T cells

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Statements Author contributions JX and CM conceived and designed the work

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It should be taken into account that carnitine synthesis is a reasonably slow process and does not readily keep up with fast changes of the metabolic requirements in stress conditions [14]