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GLP-1 medicines (Glucagon-Like Peptide-1 receptor agonists) are a class of drugs used to manage Type 2 diabetes and, increasingly, obesity and weight-related metabolic conditions
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Experimental treatments and design A preliminary experiment showed that a concentration of 5 mM 5-oxp was most effective in promoting the growth of perennial ryegrass under heat stress, as revealed by the plants treated with this concentration exhibiting less electrolyte loss and higher chlorophyll levels under heat stress (Supplemental figure 1)
"We do not yet fully understand how GLP1RA work, but these and other studies are showing that weight loss alone cannot completely account for the many kidney, metabolic, and kidney benefits that these agents provide," said Neha Pagidipati, MD, MPH, FACC , JACC associate editor
Furthermore, the osteoprotegerin (OPG)/Receptor Activator of Nuclear Factor B Ligand (RANKL) pathway is regulated by GLP-1RAs, increasing the OPG/RANKL ratio to inhibit osteoclast formation and promote bone formation by upregulating osteogenic genes like OC, COL1, Runx2, and ALP [120, 121]