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The rectal route of administration can be particularly useful for patients who have difficulties with oral ingestion or for those who require a rapid onset of action

(2023) 9:e14199

A common feature of many of these neurotoxic compounds, such as rotenone, paraquat, or MPTP, is the inhibition of mitochondrial complex I, followed by the overproduction of ROS, ATP exhaustion, and induction of a wide range of abnormalities that can elicit neuronal and astrocytic cell death [54]

In the current study, the dose of glutathione was 300 mg/day

You do not always have to follow a heavily marketed option

Some have a benzofuran ring instead of the chroman ring of vitamin E, e.g., BO-653