PMID: 15606130
Contribution statement JJM and MAN contributed to study conception and design, acquisition, analysis and interpretation of data, and drafting of the article
The Precision Peptide Genetic Test identifies common predispositions in key GLP-1 receptor variants (GLP1R rs6923761), glucose-dependent insulinotropic peptide receptor pathways (GIPR rs1800437), and melanocortin-4 receptor signaling (MC4R rs17782313)
Do GLP-1s and GIPs affect muscle mass, and how can muscle be supported during treatment
These findings suggest that the addition of GLP-1 receptor agonists to metformin therapy may mitigate certain serious adverse effects associated with metformin monotherapy
A clinical trial published in the New England Journal of Medicine (July 2, 2015) reported that over the course of a year, people injecting liraglutide lost 12 pounds more than people taking a placebo