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Statements Author contributions FY and FZ: Writingoriginal draft, XL, XH, JL, YL, and SL: Validation, XH: RL and YL review and editing

Secondly, although the downstream mevalonate pathway intermediate HMG-CoA is rapidly depleted in the absence of ACLY and acetate, acetyl-CoA levels decrease more moderately upon acute acetate withdrawal 8

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They illustrate the collaboration of molecules, cells, and tissues in regulating processes such as nutrient degradation, molecule production, and reproductive activity