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Peroxisome proliferator-activated receptor alpha (PPARa), a ligand-activated transcription factor of the NR1C nuclear receptor subfamily (alongside PPAR and PPAR/) [18], serves as a master regulator of fatty acid metabolism and lipoprotein genes, while concurrently suppressing pro-inflammatory pathways [19, 20]

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Inflammation 37(6):19761983 Tousif MI, Nazir M, Riaz N, Saleem M, Tauseef S, Azam SM, Zengin G (2023) Terpenoids as human neutrophil elastase (HNE) inhibitors: a comprehensive review of natural anti-inflammatory isoprenoids

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They may be a good choice if you are obese, morbidly obese, diabetic, prediabetic or have chronic conditions that become riskier when you are overweight