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And fiber can help combat constipation that a GLP-1 can cause

however, they exert differential effects on glucagon, with GIP stimulating glucagon release during hypoglycemia and GLP-1 suppressing it under hyperglycemic conditions [104]

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Moreover, a recent study reported that activation of peroxisome proliferator-activated receptor-/ could protect rat pancreatic cells from PA-induced apoptosis through upregulation of GLP-1R expression 31

Biological Plausibility: Why GLP-1 Agents May Reduce Risk The preventive signal observed with GLP-1 therapy is biologically plausible and likely multifactorial