Cancer 109(6):1152-1156, 2007
The drug is a once-a-week injection that combines two hormones, GLP-1 and GIP, which work in combination to stimulate insulin secretion and reduce appetite
Costs vary widely, and oral forms are not always less expensive than injectables
To overcome this limitation, various modifications and delivery strategies to enhance the pharmacokinetic properties and therapeutic efficacy of GLP-1 analogs have been studied
Months 3, 5, 7: Technical progress reports detailing technical progress made, tasks accomplished, major risks/mitigations, a technical plan for the remainder of Phase II (while this will normally report progress against the plan detailed in the proposal or presented at the Kickoff briefing, it is understood that scientific discoveries, competition, and regulatory changes may all have impacts on the planned work and DARPA must be made aware of any revisions that result), planned activities, trip summaries, and any potential issues or problem areas that require the attention of the DARPA PM