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Low levels can contribute to brain fog, irritability, and even mild depression

doi:10.1073/pnas.082119899

Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198. PMID: 24717514; PMCID: PMC4107212

10.1042/bst0290345 150

Hatzichristodoulou G, Osmonov D, Kubler H, Hellstrom WJG, Yafi FA

People who are overweight can understand their affliction with the help of their body mass index or their waist size