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Mechanistic underpinnings center on collagen/elastin/GAG upregulation and antioxidant signaling described above

VIP and immune cell modulation VIP interacts with multiple immune cells through specific receptors (VPAC-1, VPAC-2, CRTH2, and PAC1) expressed on eosinophils, mast cells, neutrophils, lymphocytes, dendritic cells, NK cells, and macrophages

Across many cultures, people eat a wide variety of fermented foods that contain probiotic strains, including yoghurt, kefir, sauerkraut, tempeh, and kimchi (174)

Hyperpigmentation Tretinoin can be effective in treating hyperpigmentation issues such as melasma and post-inflammatory hyperpigmentation

And, most importantly, this increase occurred rapidly (within hours) [9]