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Nutr J (2014) 13:60

doi: 10.1038/cdd.2016.97 25 ClarkJSFaisalABaligaRNagamineYAranyI

Br J Clin Pharmacol 81:10211029

Significantly lower levels of high-energy phosphates, such as ATP and PCr, as well as reduced oxidative phosphorylation, have been observed in patients with migraine and are closely linked to insufficient mitochondrial energy reserves ( Animal studies have shown that migraine is associated with mitochondrial dysfunction