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More recent mechanistic studies have expanded this framework by identifying specific microbiota-derived metabolites that link diet to cardiometabolic risk, notably trimethylamine N oxide (TMAO)

Specifically, preclinical studies on long-acting glucagon-like peptide 1 (GLP-1) receptor agonists have shown encouraging results in the context of disease-modifying therapeutic potential in AD

Endocrine Practice , 30 (10), pp.978-986

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During the persistent caloric deficit that GLP-1 therapy creates, meeting elevated EAA requirements becomes essential for preserving muscle anabolic sensitivity