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It comes down to what your protocol actually requires

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It acts as a cofactor for methionine synthase, which is required for the production of SAMe, the methyl donor involved in synthesis of serotonin and dopamine

If you struggle to consume enough vitamin B-12 through diet, vitamin B-12 shots get easily absorbed into your bloodstream and are a great way to bump up the intake and minimize the risks associated with the deficiency.

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