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Insulin prepared in neutral solutions containing phenol showed reduced deamidation probably because of its stabilizing effect on the tertiary structure (-helix formation) around the deamidating residue, which lowered the probability for formation of intermediate imides (53)

The small-molecule cocktail induced extra-embryonic endoderm (XEN)-like cells from fibroblasts bypassing the pluripotent state, which could differentiate towards hepatocytes (Li et al., 2017b)

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