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10.1002/path.2913 7 AmengualJ

From the above experiments, total enzymatic rates (actual enzymatic plus non-enzymatic rates) were obtained

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The ability of GH and IGF to modulate key signal transduction pathways such as the MAP kinase/ERK, Jak/STAT, and the PI3K/Akt pathway along with the subsequent effects on cell division and steroidogenesis indicates that these growth factors are centrally located to alter cell fate during proliferation and survival