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Some additives, such as boric acid derivatives, have been incorporated into the organic polymer phase to counteract the effects of lipophilic amine by-products generated during NO release on the pH of the organic phase, which can minimize the pH rise in the organic polymer phase and prolong the release period of NO [72]
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The antinociceptive effect of ALC has been confirmed in several experimental models of neuropathic pain, including streptozotocin- and chemotherapy-induced neuropathy, and the sciatic nerve chronic constriction injury model
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