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Slow IV injection is an option when immediate availability of the vitamins is desired or if the patient is already receiving IV fluids

Freezing reconstituted peptides is not recommended for regular use because freeze-thaw cycles cause aggregation and loss of activity

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Oxidized peptides may show reduced activity and mass shifts

doi: 10.3389/fphys.2020.00435 Received 30 December 2019 Accepted 08 April 2020 Published 20 May 2020 Volume 11 - 2020 Edited by Lars Kaestner, Saarland University, Germany Reviewed by Carina Levin, HaEmek Medical Center, Israel