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An additional indicative point is sequential involvement

Working in a job that requires exposure to heavy metals or radiation

In addition to being a therapeutic target, oxidative stress has been shown to decrease the GSH:GSSG ratio which has proven useful as a clinically accessible, pharmacodynamic biomarker of immune redox tone for conditions such as malignancy (Zitka et al., 2012)

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The leached amount would be attributed to the poor association/adsorption of a small fraction of the AuNCs with/at the surface of PLGA in resemblance to the known burst release of encapsulated drugs in PLGA nanohosts

Rost NS, Brodtmann A, Pase MP, van Veluw SJ, Biffi A, Duering M, et al