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Common side effects (affecting up to 1 in 10 people): Vomiting Constipation Abdominal pain or discomfort Dyspepsia (indigestion) Decreased appetite Hypoglycaemia (low blood sugar), particularly when used in combination with insulin or sulphonylureas Injection site reactions (redness, itching, or bruising) Less common but important side effects: Acute pancreatitis: Characterised by severe, persistent abdominal pain that may radiate to the back
With more receptors, neurons attempt to restore the signals to normal
However, for the first time, abnormal stimulation of Nrf2 has been observed in non-small cell lung cancer with mutations (Padmanabhan et al., 2006)
It is often used consistently over time rather than on an as-needed basis
We don't get a lot of glutathione in our diet, and even then, not much is absorbed directly into the blood