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These agents are particularly useful as add-on therapies but may also suffer from incomplete CNS penetration and systemic side effects such as hypertension and insomnia due to their off-target activity

NLRs-Inflammasome Pathway: DAMP-mediated NLRP3 Inflammasome Activation, Pyroptosis, and IL-1 Release Activated NLRs manifest diverse functionalities, which can be comprehensively classified into four primary functions: inflammasome formation, signal transduction, transcriptional activation, and autophagy

Central sensitization develops when the nervous system remains in a prolonged stress or threat state

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Effective protection from UVA and UVB sun rays

Katschinski DM, Neustock P, Kluter H, Kirchner H