6 While many of these agents, such as RAAS blockers, effectively attenuate adverse general cardiac remodeling and improve survival by targeting specific signaling pathways, significant gaps remain in addressing key disease-driving mechanisms, such as chronic inflammation, fibrosis, and metabolic dysregulation
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doi: 10.1155/2013/424163 202 PaparoSRFerrariSMPatrizioAEliaGRagusaFBotriniCet al
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