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However, carnitine is a vital metabolite for the heart as it is necessary for the transfer of long-chain fatty acids across the inner mitochondrial membrane for beta-oxidation
and our targeted LCMS data demonstrate a profound change in broad metabolic activity in cells, supported by RNA-seq analysis of metabolic gene expression changes
Concurrently, liver insulin resistance promotes de novo lipogenesis ( de novo lipogenesis through sterol regulatory element-binding protein 1c (SREBP-1c) activation, increasing the synthesis of triglycerides and very-low-density lipoproteins (VLDL), contributing to MASLD and systemic dyslipidemia Figure 4 (50, 52, 53)
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