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A previous study showed that curcumin, a plant-derived tetra-terpenoid obtained from Curcuma longa , can inhibit the activation of PI3K/AKT pathways by suppressing the insulin like growth factor or IGF1 (the upstream cytokine of PI3K/AKT pathway) in RA fibroblast-like synoviocyte (RA-FLS) cell line 54

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Baseline body mass index (BMI) significantly influences absolute weight loss, with individuals having higher starting weights typically losing more total pounds, though percentage weight loss remains relatively consistent across BMI categories

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10.1016/j.intimp.2007.04.005 203 MorenoM.GiraltE