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in the context of retatrutide, this effect is thought to be counterbalanced by concurrent GLP-1 and GIP receptor activity, though the precise interplay in humans remains an area of ongoing investigation

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Effect of combination therapy with thyroxine (T4) and 3,5,3-triiodothyronine versus T4 monotherapy in patients with hypothyroidism, a double-blind, randomised cross-over study

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Less muscle means the body is burning fewer calories around the clock, making the plateau deeper and the path forward narrower