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Glucagon-like peptide-1 receptor agonists associated gastrointestinal adverse events: a cross-sectional analysis of the National Institutes of Health All of Us Cohort

2 Pathophysiology and molecular mechanisms of Parkinsons disease Parkinsons disease (PD) is a multifactorial neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc)

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The incremental number of QALYs associated with SGLT2i use was projected at 29,357, and widespread use of SGLT2is was projected to lead to an incremental healthcare cost of AU$0.3 billion, resulting in an ICER of AU$8878 per QALY gained

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In addition, the pentacyclic triterpenoid saponin anemoside B4, despite potent anti-inflammatory and antioxidant activities, exhibits low oral bioavailability that limits its application potential (Wen et al., 2026)