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[8] With rapamycin, inhibition of mTOR is due to the binding of rapamycin to the FK506 binding protein (FKBP12), which allosterically inhibits mTORC1

As such, their use is generally limited to a few administrations per year per joint (Bensa et al., 2024

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Liu T, Huang Y, Guo L, et al

To mask the treatment, a combination of tablets comprising the total daily dose was placed into gelatin capsules for dogs in the treatment group

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