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Summary: Rybelsus causes nausea and sickness by slowing gastric emptying and acting on brain receptors that regulate appetite, creating sensations of fullness and queasiness that typically improve after 48 weeks

This anti-allodynic effect induced by GLP-1R could be blocked by the opioid receptor antagonist naloxone [88]

[DOI] [PubMed] [Google Scholar] 89.Omotosho I.O., Akinade A.O., Lagunju I.A., Yakubu M.A

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In conclusion, targeting key regulatory molecules in ROS homeostasis-related signaling pathways holds great promise for innovative clinical therapies