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837 C3G also increases GPX4 expression and GSH level, significantly inhibiting the ferroptosis of renal tubular cells

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agonism appears to modulate lipid metabolism directly and reduce inflammatory signalling Improved glycaemic control lower blood sugar reduces the substrate available for fat synthesis in the liver A 2025 meta-analysis of 13 phase 2 and phase 3 randomised controlled trials involving 1,811 participants found that GLP-1 receptor agonists significantly reduced magnetic resonance-measured liver fat content, with a pooled mean reduction of 4.50% compared to placebo

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R-Y W, Ruvolo V, McQueen T, Schober WD, Kornablau SM, Konopleva M, Andreeff M

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