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Mehta MV, Gandal MJ, Siegel SJ

The regulatory action of the opioid system on the GIT is also related to the fact that opioid peptides are expressed by different classes of enteric neurons, mainly in myenteric neurons projecting to the sphincter and in neurons of the descending enteric tracts [66]

The mechanism may involve modulation of somatostatin (GH inhibitory hormone) release from the hypothalamus, or interaction with GHRH neurons

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Patients should consult a licensed healthcare provider to determine appropriate care