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Selective NNMT inhibitors (including 5-Amino-1MQ) lower 1-MNA, increase NAD and SAM, suppress adipocyte lipogenesis, and reverse HFD-induced obesity in mice [1]

These characteristics support its use in ameliorating obesity-related gastrointestinal dysfunction, helping patients establish regular eating patterns, reducing gastrointestinal irritation from overeating, and alleviating postprandial discomfort such as bloating and indigestion

No multi-center RCT

Houen, G

This approach, characterized by alternating caloric intake, proposes an innovative method to enhance fat loss and boost metabolic effi