Insulin resistance affects neurotransmitter function
However, this effect is minimised as there are comparable numbers of subjects on metformin in either the high or low GLP-1 groups
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Furthermore, a pooled analysis of four trials showed that tolerability improved over time, demonstrating that sensitivity to gastrointestinal AEs decreased with prolonged exposure (17)
This study did not find higher rates of gallstones, often associated with weight loss, with these drugs, and found fewer episodes of ileus, or blocked colon, than expected based on age and other medical conditions