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J Biol Chem 279:891929 Kong AN, Yu R, Hebbar V, Chen C, Owuor E, Hu R, Ee R, Mandlekar S (2001) Signal transduction events elicited by cancer prevention compounds

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It seems in pre-clinical models that when these L-cells are exposed to perceived toxins, such as lipopolysaccharides from certain bacteria that this triggers a surge in endogenous GLP-1 which is perhaps the bodys way of using GLP-1 as an anti-inflammatory hormone or perhaps as a brake pedal on the inflammatory response in general