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This study leveraged a large, multicenter real-world database and employed propensity score matching to strengthen methodological rigor and reduce the influence of measured confounders

Upon activation by conditions inducing ER stress, CHAC1 expression is upregulated primarily through the PERK-eIF2-ATF3/4 signaling pathway, independent of other UPR branches like IRE1-XBP1

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Therefore, it is a crucial factor in the treatment of retinal ischemia-reperfusion to urgently develop a therapy that can regulate many programmed cell death (PCD) pathways