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Sulphonamide-based bombesin prodrug analogues for glutathione transferase, useful in targeted cancer chemotherapy

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Pharmacokinetic and toxicity predictions suggest that the lead compounds have drug-likeness properties

Finally, we consider factors that could limit the impact of these therapies, outlining reasons why our expectations may not be fully realized

Summary: GLP-1 receptor agonists are not formally associated with leg cramps, but indirect mechanisms such as dehydration and electrolyte imbalances from gastrointestinal side effects may contribute to muscle cramping in some patients