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SGLT2 inhibitors have demonstrated robust reductions in hospitalisation for heart failure across risk groups, with cardiovascular death benefits most clearly established in heart failure trials
This means semaglutide reaches steady state slightly later but maintains more consistent blood levels between doses
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Treatment with semaglutide demonstrated sustained, statistically superior and clinically significant reductions in HbA1c and body weight for up to 2 years compared to placebo and active control treatment (sitagliptin, insulin glargine, exenatide ER and dulaglutide)