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As shown in Table 3 , the antibacterial properties of plant extracts are attributed mainly to their phenolic compounds (337, 338)

Collectively, the complex interplay among gut microbiota, nutrient-sensing pathways, and metabolic health highlights the promise of microbiota-targeted strategies in addressing various metabolic diseases

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At the same time in the lung, senescence or fibrosis induced PDGF activates fibroblasts, reactivating DTCs (162)

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In theory, combining agents that both reduce adiposity and improve insulin sensitivity could produce additive or synergistic metabolic effects but this is entirely speculative and unproven in humans