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4,207,208 The resultant neuronal hyperexcitability and microglial activation lead to chronic neuropathic pain

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This is also when you are most likely to experience side effects like headaches , fatigue, and gastrointestinal discomfort as each new dose level requires readjustment

Given the role of low grade inflammation in obesity, this approach may counter insulin resistance and metabolic dysfunction, and could be useful in T2D, autoimmune disorders, or neurodegenerative diseases [10, 12, 27,28,29]

doi: 10.1016/j.lfs.2005.12.001

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