In a combined fertility and prenatal and postnatal study in male and female rats at subcutaneous doses up to 0.36 mg/kg/day, which was approximately 50 times the recommended human subcutaneous starting dosage of 0.2 units/kg/day (0.007 mg/kg/day) maternal toxicity due to dose-dependent hypoglycemia, including some deaths, was observed
For a more comprehensive breakdown, our guide on supplementation during GLP-1 agonist use covers additional considerations including B-vitamins, probiotics, and digestive support
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If you're currently on a prescription GLP-1 injection and you're thinking about switching, please speak to your healthcare provider first
Kim KS, Egan JM, Jang HJ
Retatrutide is therefore not available as a licensed medicine in the UK, and any use outside of approved clinical trials would be unlicensed and potentially unsafe