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Due to lack of research on prolonged ketosis in the context of TBI, the extent to which adverse events of ketogenic diets could impact the unique pathological state of these patients remains a concern for many physicians that recognize its clinical potential [106]

[6] Shukla S, Srivastava JK, Shankar E, et al

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Retinoids present a similar conflict

Indeed, high NAD + levels and NAD + /NADH ratios are associated with increased energy production in humans, improved mitochondrial membrane potential, and decreased mitochondrial mass through mitophagy in vitro, suggesting improved efficiency of mitochondria 94,95,96,97