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Heme oxygenase-1 (HO-1), a cytoprotective enzyme, possesses anti-inflammatory properties and is involved in ferroptosis (145)

Side-effects and possible issues with long-term use of these novel agents have yet to be fully evaluated

Studies show patients who lose weight often experience compensatory increases in hunger hormones like ghrelin and decreases in satiety hormones like PYY

Liraglutide brand names Liraglutide is available under two main brand names: Saxenda: FDA-approved for chronic weight management Victoza: FDA-approved for type 2 diabetes management In 2024, the FDA also approved a generic version of Victoza, which can now be used for type 2 diabetes treatment

As we know, proteins involved in p-p38 and p-JNK are MAPKs pathways and p-AKT are all proteins belonging to PI3K/Akt pathway

Key points Diabetic sensorimotor peripheral neuropathy (DSPN) is a common complication of diabetes mellitus that is associated with increased mortality, neuropathic pain, foot ulceration and lower-limb amputation