Rituximab is associated with worse COVID-19 outcomes in patients with rheumatoid arthritis: a retrospective, nationally sampled cohort study from the U.S
I am still somewhat in shock from this data and know that even more shocking results await in the full data of Triumph 1, 2 and 3
In 2025, Novo Nordisks semaglutide awaits several first-time FDA decisions: 3Q 2025 the first GLP-1 (Wegovy) for metabolic dysfunction-associated steatohepatitis (MASH) 4Q 2025 the first oral GLP-1 ( oral formulation of Wegovy 25 mg ) for weight loss and weight loss plus secondary CV risk reduction 4Q 2025 Wegovy for heart failure with preserved ejection fraction and obesity October 2025 new indication for oral Rybelsus for secondary CV risk reduction 2025 Ozempic for T2DM and peripheral artery disease (PAD) Given the considerable continued growth expected in the GLP-1 pipeline, Prime Therapeutics (Prime) talented team of clinical experts actively monitors this emerging landscape
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GLP-1s illustrate this well: injectables lead today because they deliver better clinical outcomes, while continued oral innovation reflects market expansion and access potential for a larger patient population. Groups continue to innovate the ways in which peptide- and protein-based biologics (including GLP-1 medications) are administered
On the other hand, ALC has demonstrated effects in models of depression in rodents exposed to unpredictable chronic stress through a possible epigenetic regulation of metabotropic glutamate type 2 (mGlu2) receptors