Tirzepatide and semaglutide are not identical in side effect profile, despite sharing the GLP-1 receptor pathway
The numbers were not incremental improvements over existing options
If hypoglycaemia occurs (symptoms include tremor, sweating, confusion, and palpitations), treat with 15-20g of fast-acting carbohydrate (e.g., glucose tablets, fruit juice), retest after 10-15 minutes, and follow with a longer-acting carbohydrate if needed
Giovannucci, C
The altered gastrointestinal anatomy may affect absorption, and injectable GLP-1 receptor agonists like Ozempic may be more reliable alternatives as they bypass the digestive tract entirely
The peptide is clasped between the N-terminal domain and the transmembrane core of the receptor, and further stabilized by extracellular loops