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However, if PLP levels exceed 200 nmol/L or if you develop numbness or tingling in the extremities, discuss with your provider about potential B6 accumulation

Replacement of the C-terminal Trp-cage of exendin-4 with a fatty acid improves therapeutic utility

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It says metformin remains first-line for type 2 diabetes and prediabetes, supported by decades of safety data and cardiovascular benefit evidence, while GLP-1 agonists have emerged as adjuncts for glycemic control, weight management and cardiovascular risk reduction