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Br J Nutr 2009;102:1642-53

In SURPASS-2, severe hypoglycemia (requiring third-party assistance) occurred in fewer than 0.6% of tirzepatide-treated participants not on sulfonylureas or insulin, mechanistically expected given the glucose-dependent clamp

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We also generated a strep-MBP-ROXY9-CPYC derivative in order to ask the question whether the class III GRX-specific second cysteine might interfere with catalytic activity

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