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According to NICE guideline NG28, GLP-1 receptor agonists like Rybelsus may be appropriate as a second-line or third-line option when: Metformin is contraindicated or not tolerated The patient has a body mass index (BMI) of 35 kg/m or higher (adjusted for ethnicity), or there are specific psychological or medical problems associated with obesity Weight loss would benefit other significant obesity-related comorbidities Patients who strongly prefer oral medication over injectable therapies may be suitable candidates for Rybelsus

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[DOI] [PubMed] [Google Scholar] 39.Franco R., Schoneveld O.J., Pappa A., Panayiotidis M.I